radiotherapy

Radiation therapy is used to treat tumors. Precise administration of a radiation dose kills the cells in the area being treated. The aim is to spare the surrounding tissue as much as possible. Radiation has also proven effective in relieving pain associated with osteoarthritis.

INHALT
Areas of application Functionality procedure side effects
Areas of application

Alongside surgery and chemotherapy, radiation therapy is an important pillar of tumor treatment (see corresponding article). Depending on the severity of the disease, a distinction is made between curative and palliative treatment. The aim of curative treatment is to cure or control the tumor in the long term. If this is no longer possible, palliative treatment can slow down tumor growth and improve the animal's quality of life.

Radiation therapy is also used to treat the following conditions:

  • Severe painful osteoarthritis
  • Sialoceles (=saliva-filled cysts)
  • Lick granulomas
  • Immune-mediated (= caused by the immune system itself) meningoencephalitis (= inflammation of the brain and meninges)
  • Idiopathic (=unknown cause) meningoencephalitis

Functionality

In veterinary medicine, linear accelerators are usually used as irradiation devices. These generate high-energy electrons (= negatively charged elementary particles, components of atoms). The electrons are accelerated to high speeds and then emitted directly from the device as a beam. This allows superficial tumors to be irradiated. High-energy photons (light particles) must be used to irradiate deeper-lying tumors. These are generated by first striking the electrons in the linear accelerator against a plate made of tungsten (a metal). The photons created by the impact on the plate then emerge from the device as an electromagnetic beam.

The radiation used in therapy damages the DNA (=genetic material) of cells, which then lose their ability to divide. Radiation therapy specifically exploits the differences between healthy and tumor cells: both healthy and tumor cells only live for a limited time and are continuously replaced by cell division. During cell division, cells are particularly sensitive to radiation. Unlike healthy cells, tumor cells divide frequently and are therefore more susceptible to damage from radiation due to this high division rate. Every cell has a repair system for damaged DNA. However, this works better in healthy cells than in tumor cells. Healthy tissue therefore recovers from radiation, while tumor cells die.

The exact processes by which radiation reduces inflammatory reactions, such as in osteoarthritis (see related article), are not yet fully understood.

procedure

In order to determine the exact location and size of a tumor, a planning computed tomography (CT, see corresponding article) is often performed in advance. This is not usually necessary for the irradiation of a superficial tumor. The optimal positioning of your animal for radiation therapy is then determined. Rigid head masks and vacuum cushions can be custom-made to ensure that your pet is positioned exactly the same way in each radiation session. The radiation field (the area to be irradiated) is calculated with a safety margin to protect vital organs. In the head area, these include the brain and eyes.

An individual radiation plan is then created, specifying the number of sessions and the radiation dose. The aim is to irradiate the tumor with the highest possible dose, but to irradiate the surrounding tissue with as low a dose as possible. The radiation plan depends on the type and location of the tumor, as well as the general condition of the animal and any other existing diseases. Typically, five radiation sessions per week take place. In contrast to curative treatment, palliative treatment often involves fewer sessions with a higher radiation dose. For radiation therapy for osteoarthritis, only a few sessions are required with a very low dose compared to tumor radiation.

Radiation therapy is an outpatient treatment. The radiation itself only takes a few seconds. To ensure accurate radiation, your pet must not move. Therefore, it must be placed under short anesthesia for each radiation session. After monitoring the recovery phase, your pet will be released to go home.

side effects

Acute radiation reactions occur primarily during curative radiation therapy. They can develop after two to three weeks of radiation treatment. Hair loss, skin redness, and inflammation of the skin or mucous membranes may occur in the area exposed to radiation. These changes usually heal on their own within a few weeks after the end of radiation therapy. The fur takes a little longer to grow back. In most cases, it grows back white. Acute radiation reactions are treated with painkillers and anti-inflammatory drugs and, if necessary, antibiotics. To protect the affected area, your pet should wear a neck collar or a protective bodysuit.

Chronic radiation reactions only occur months to years after the end of radiation therapy. They occur mainly in palliative radiation therapy. In animals with a low life expectancy due to tumors, this is accepted. However, treatment plans are calculated in such a way that late radiation reactions occur very rarely. These can manifest themselves in:

  • Changes in coat color
  • Cataract formation (see corresponding article)
  • Fibrosis (=hardening) of the skin and connective tissue, resulting in narrowing of, for example, the urethra or the gastrointestinal tract
  • Tissue necrosis (=death of tissue)

Secondary tumors can also develop very rarely as a result of radiation. At the edge of the radiation field, these are usually osteosarcomas (see corresponding article). Tumors can also develop in areas of the body that were further away from the radiation field but were still exposed to a low dose of radiation. Secondary tumors take several years to develop. Therefore, this risk is only relevant in young animals.

Since radiation is only administered locally in the area of the tumor, side effects such as nausea, dizziness, or vomiting are unlikely.