Rabies – back in the news?

Rabies is a viral infection that has been known for thousands of years. Most mammals, including humans, are susceptible to it, and it can also be transmitted between animals and humans (zoonosis). The infection caused by the rabies virus almost always results in fatal brain inflammation. Rabies is a notifiable animal disease in Germany, which means that even suspected cases must be reported to the competent authorities. Germany has been recognized as free of rabies in non-flying animals since 2008. It continues to occur in bats.

INHALT
Cause and origin Symptoms Diagnosis Treatment Forecast Prophylaxis
Cause and origin

The pathogen that causes rabies is the rabies virus. It is transmitted through bites, scratches, or contact with the saliva of infected animals. The virus multiplies at the site of entry and penetrates the nerve fibers within 24 hours. The virus travels along the nerves toward the spinal cord and brain. The virus multiplies and spreads rapidly, particularly in the brain. From there, it spreads via the nerves to all organs, preferentially to the salivary glands and the eyes. The virus can be excreted in saliva, and less commonly in urine, feces, or breath, as early as three to 13 days before symptoms appear.

Rabies virus
Electron microscope image of the rabies virus
Symptoms

The incubation period for rabies is two to eight weeks and depends largely on how far the virus is from the brain. The shorter the distance, the faster the first noticeable symptoms appear. The brain inflammation caused by the virus is responsible for most of the symptoms observed. Behavioral changes are often the first signs of rabies. Affected animals become aggressive, overexcited, and may show signs of impaired consciousness. Animals that were previously fearful may become unusually trusting. As the disease progresses, paralysis, excessive salivation, and difficulty swallowing occur. The affected animals die within a few days to a maximum of one week.

Classic rabies is therefore divided into three stages: the prodromal stage (initial stage), the excitation stage (rabid rage), and the paralytic stage (silent rage). However, forms of the disease have also been observed in which the rabid stage and the associated aggression are completely absent and the disease begins with paralysis. Atypical forms are also possible, with gastrointestinal symptoms.

Diagnosis

A definitive diagnosis can still only be made with the help of laboratory tests on the dead animal. The pathogen can be detected directly in the brain tissue. In living animals, only a suspected diagnosis can be made based on the symptoms. As rabies is a notifiable animal disease, your veterinary practice must notify the competent authority without delay as soon as rabies is suspected. The official veterinarian will then take the necessary steps to prevent the virus from spreading further.

Treatment

To date, there is no known cure for rabies once it has broken out. Due to the high risk of infection for humans, the treatment of animals infected with rabies is prohibited in Germany. If rabies is suspected, the responsible official veterinarian may order the immediate isolation and euthanasia of the affected animal. All relevant legal provisions are set out in the Rabies Ordinance.

Forecast

Once contracted, rabies is always fatal. An outbreak of the disease can only be prevented if your pet is vaccinated against rabies immediately after coming into contact with a rabid animal.

Prophylaxis

The main host for the rabies virus is the fox. In Germany, therefore, oral vaccinations were administered across the board in endangered areas until 2008. Thanks to additional intensive fox hunting, fox rabies has been controlled to such an extent that Germany has been considered free of terrestrial rabies (= rabies in non-flying animals) since 2008 according to the criteria of the World Organisation for Animal Health (OIE). In rare cases, infection with bat rabies is still possible.

The vaccine developed by Louis Pasteur in 1887 and used worldwide ever since protects not only your pet, but also you.

In Germany, the Rabies Ordinance requires certain vaccination intervals for dogs, cats, and ferrets. If an animal that has not been vaccinated against rabies comes into contact with a rabid or suspected rabid animal, massive official measures are ordered to protect humans and other animals. In this case, however, properly vaccinated dogs, cats, and ferrets may be kept at home under official observation.

In the EU, vaccination against rabies is mandatory for cross-border travel with dogs, cats, and ferrets. Furthermore, there may be country-specific entry requirements. Rabies vaccination is recommended for horses when they are transported to countries where rabies is still present.

Preventive vaccination

The Rabies Ordinance requires the initial vaccination of dogs and cats from the age of twelve weeks. The basic immunization consists of three consecutive vaccinations at the ages of twelve and 16 weeks and 15 months. Booster vaccinations are then necessary at intervals of three years.

For ferrets, vaccination from the age of twelve weeks in accordance with the manufacturer's instructions is sufficient for compliance with the Rabies Ordinance.

For horses, a single vaccination from the age of six months is sufficient as basic immunization, followed by booster vaccinations every three years.

There are pure rabies vaccines, but combination vaccines are often used for dogs and cats, which protect against other diseases in addition to rabies. Your vet can send you a personalized vaccination schedule for your pet via petsXL, and you will automatically receive notifications when it is time to make another appointment.

Post-exposure vaccination

Another way to protect against rabies is to vaccinate immediately after being bitten by an animal suspected of having rabies. This preventive vaccination is particularly effective if the site of the bite is as far away from the central nervous system as possible and no blood vessels have been damaged. This type of vaccination consists of passive immunization (antibodies against rabies) and active immunization (preventive vaccination). Half of the passive vaccine is injected directly into the bite wound or injury. The rest is injected into the muscle, just like with preventive vaccination, but at a site far away from the bite site so that the two vaccines do not neutralize each other. If symptoms have already appeared, this vaccination can no longer cure the disease.