Mitral valve endocardiosis – when the heart valves no longer close properly

Mitral valve disease (MMVD) is a chronic degenerative disease of the heart valves. It is the most common heart disease in dogs and mainly affects older dogs of smaller breeds. An exception is the Cavalier King Charles Spaniel, which often develops the disease at the age of 1.5 to two years.

INHALT
Cause Anatomy and development Classification Symptoms Diagnosis Treatment Forecast Prophylaxis
Cause

The exact causes of the tissue changes are unknown. However, scientific studies now suggest that it is essentially a hereditary condition that is influenced by other factors (environment, diet).

Anatomy and development

There are four heart valves in the heart. The pocket valves are located between the ventricle and the outflow vessel, and the sail valves are located between the atrium and the ventricle. The valves act as valves and prevent blood from flowing back in the wrong direction.

The mitral valve is an aortic valve and is located between the left atrium and the left ventricle. It prevents blood from flowing back into the atrium during the contraction phase. In the case of MMVD, there is a non-inflammatory change in the tissue structure of the valves. They thicken and the valve edges can curl inwards, so that the valve can no longer close completely and thus becomes leaky. This leads to an increasing backflow of blood into the left atrium.

This results in progressive enlargement of the left atrium and left ventricle. The extra work that the heart muscle has to do can be compensated for by the heart itself over a long period of time, so that the patient does not experience any clinical symptoms. However, when this is no longer possible, blood backs up into the lungs, gradually causing pulmonary edema (fluid in the lungs).

Heart diagram
1 Aorta | 2 Tricuspid valve | 3 Pulmonary valve | 4 Right ventricle | 5 Pulmonary artery | 6 Left atrium | 7 Altered mitral valve | 8 Aortic valve | 9 Left ventricle
Classification

The disease is classified into different stages based on the extent of valve leakage and subsequent heart enlargement.

The classification is based on the CHIEF classification (=Canine Heart Failure International Expert Forum). This expert committee has published a uniform classification of heart disease in dogs.

The diseases are divided into the following four stages:

A = increased risk of heart disease (genetic predisposition, previous illness)

B = heart disease without symptoms

B1 = without heart enlargement

B2 = with heart enlargement

C = heart disease with previous or existing symptoms

C1=stable heart failure with previous symptoms (treated)

C2=Heart failure with mild to moderate symptoms

C3 = heart failure with severe, life-threatening symptoms

D = heart failure that no longer responds to medication, measures only life-sustaining

Symptoms

The disease develops gradually and can remain symptom-free for many years. Dogs with MMVD in stage B1 show no heart enlargement and no symptoms whatsoever, so the disease is usually only discovered by chance during routine veterinary examinations. The veterinarian will notice an abnormal heart sound caused by the backflow at the diseased valve.

In stage B2, the heart has already enlarged due to the increasing backflow of blood and there is a much greater risk that the disease will progress more rapidly, even if the animal still shows no symptoms.

In the more advanced stage C, clear signs of disease are noticeable. The backflow of blood into the lungs and the resulting accumulation of fluid (pulmonary edema) in the lungs causes coughing and breathing problems. The poor heart function can also lead to weakness, fainting spells, and weight loss.

If respiratory symptoms continue to worsen, heart disease should always be considered and the animal should be taken to a veterinarian immediately.

IMPORTANT: Acute respiratory distress or recurring fainting spells are always an acute emergency that requires veterinary treatment as soon as possible!

Diagnosis

Since the symptoms are not characteristic and can also occur in many other diseases, it is very important that your dog is thoroughly examined by a veterinarian. In addition to the clinical examination, your preliminary report is also very important for the veterinarian, as it provides valuable information about the onset, occurrence, and severity of the symptoms.

The general examination is followed by a special examination of the heart. First, the heart is listened to (auscultation) and palpated. In most cases, an initial diagnosis can be made based on the audible heart sounds. However, to confirm the diagnosis, an ultrasound examination of the heart is essential, as this allows the backflow of blood to be accurately visualized and measured. In addition, X-rays, ECG (electrocardiogram), and blood pressure tests can confirm and further specify the diagnosis.

Heart ultrasound for dogs
The extent of valve leakage is visible on ultrasound
Treatment

Since the changes to the valves are irreversible, treatment is limited to slowing the progression of the disease and alleviating the symptoms. It is important to note that the appropriate medication must therefore be administered for life.

Veterinarians now have a variety of heart medications available to treat MMVD, which they can use depending on the type and severity of the disease. These include diuretics and heart-strengthening drugs. With the help of these medications, dogs in stages B and C can be helped so effectively that they can continue to live a virtually symptom-free life.

Your vet will draw up a detailed treatment plan for your individual case and can send the medication for your dog digitally to petsXL , so that you can find all upcoming medication doses in your timeline and set reminders for yourself.

The medication should be accompanied by an appropriate low-sodium diet. The affected animal should continue to get regular gentle exercise, but extreme physical exertion and forced exercise (jogging, cycling) must be avoided. You can easily check your dog's breathing rate yourself by counting each rise and fall of the chest while they are sleeping. The breathing rate at rest should not exceed 30 breaths per minute.

Schedule regular check-ups with your veterinarian for your heart patient. This will allow the veterinarian to monitor the progression of the disease and the success of the treatment.

Forecast

The prognosis depends greatly on the severity and stage of the disease. Many dogs can compensate for MMVD well with medication throughout their lives, while others quickly become decompensated, meaning that the body is no longer able to compensate for the strain, which significantly worsens the prognosis despite treatment.

Prophylaxis

Since it is largely a hereditary condition, it is difficult to prevent the disease. However, breeding measures can help reduce the spread of the disease. Many breeding associations require heart ultrasound examinations in order to obtain a breeding license. Regular veterinary check-ups of the heart, including an ultrasound examination, should be carried out, especially in predisposed breeds, in order to detect and treat potential changes at an early stage.