Recurring eye inflammation – is my horse going blind?

Periodic eye inflammation has been known for over 2000 years and is the most common eye disease in horses. It describes a recurring inflammation of the middle layer of the eye (uvea) in horses. In veterinary medicine, the term "equine recurrent uveitis" (ERU) is now used. The disease occurs repeatedly, initially at longer intervals and later at shorter intervals, and can lead to significant visual impairment. Since the affected horses often went blind from this disease and it was suspected that it was related to the phases of the moon, it was also commonly referred to as moon blindness.

INHALT
How can I recognize an ERU? Diagnosis How does ERU develop and what are its causes? Treatment Forecast Prophylaxis
How can I recognize an ERU?

The symptoms vary greatly depending on the severity of the inflammation and are therefore often overlooked in the early stages. As the disease progresses, the symptoms increase and owners notice a squinting eye or increased tearing. Since it is not always easy for animal owners to distinguish between relatively harmless conjunctivitis and more severe internal eye inflammation (which is often accompanied by reddening of the conjunctiva), a veterinarian should always be consulted immediately if this is suspected.

Depending on their exact location, the inflammatory processes occurring inside the eye cause varying degrees of pain, which is not always equally severe in every horse. ERU is characterized by its recurrent nature, which distinguishes it from other eye infections with similar symptoms. Typical symptoms of ERU include increased tearing, severe sensitivity to light, swelling and warmth of the eyelids, severe eyelid spasms, constricted pupils and, in some cases, damage to the cornea. As the disease progresses, apathy and fever may occur.

Diagnosis

In order to make an accurate diagnosis, the animal's medical history is extremely important for the veterinarian. This is the only way to distinguish between simple and recurrent eye inflammation. In addition to a general examination, the veterinarian will perform a special eye examination using an ophthalmoscope to get a closer look at the inside of the eye and the back of the eye. In most cases, the diagnosis can be made based on the clear clinical symptoms. However, reliable detection of leptospira antibodies can only be achieved by removing fluid from the front chamber of the eye under short anesthesia. A blood test is recommended in all cases to obtain information about the horse's general health and any signs of inflammation.

How does ERU develop and what are its causes?

The uvea of the horse's eye is unfortunately very susceptible to inflammation. For this reason, various general illnesses such as strangles or other respiratory diseases can lead to eye inflammation. Despite intensive research, however, not all factors involved in the development of ERU are yet known. According to the latest findings, the following factors are possible triggers:

  • Bacteria (leptospira, streptococci, coli bacteria, and others)
  • Viruses (influenza, herpes, and others)
  • Parasites (toxoplasma, worms)
  • Fungal infections (from air sac mycosis)
  • Injuries (direct and indirect)
  • Chemical damage (vascular wall damage)
  • Allergic reactions
  • Autoimmune diseases
  • Hereditary predisposition

While leptospires in particular were long considered the primary trigger of ERU, it is now believed that the bacteria primarily break through the barrier between the blood and the eye (the so-called "blood-eye barrier"), leading to autoimmune processes in the inner eye. The periodic nature of the inflammation is caused by inflammatory products remaining in the eye, which trigger a repeated inflammatory response upon renewed contact with the antigen.

The inflammatory process can cause adhesions to form between the iris and the lens, which, together with inflammatory products that deposit on the back of the lens, can lead to lens opacity. The inflammation also causes opacities in the vitreous body with membrane-like deposits, which further restrict vision. A discolored iris and fibrin deposits in the anterior chamber of the eye can still be detected by the veterinarian even after the acute phase. Inflammation can recur as early as 4 to 8 weeks after the first episode has subsided. The intervals between individual episodes are similar at first, but can become significantly shorter as the disease progresses. The inflammation can cause damage to the cornea, lens, and vitreous body, increased or decreased intraocular pressure, and adhesions between the iris and the lens. If repeated untreated episodes of inflammation cause the retina to detach from the back of the eye, this usually leads to irreversible blindness in the horse.

Horse with eye infection
Corneal opacity resulting from periodic eye inflammation
Treatment

In the acute stage of the disease, conservative, local treatment of the affected eye is carried out. Depending on the degree of inflammation and the symptoms, pain-relieving and anti-inflammatory eye ointments or drops are used. Pupil-dilating medications are only useful if there is also severe pupil constriction. If these preparations are used, the affected eye must not be exposed to strong sunlight in the following days, as the medication prevents normal pupil reaction in the first few days. A dark box or an appropriate eye mask provides protection and prevents the retina from being damaged by excessive light. Discuss with your veterinarian which eye ointments or drops are appropriate in individual cases and whether general painkillers or anti-inflammatory drugs also need to be administered.

However, the disease cannot usually be controlled with medication alone. To prevent progressive damage to the eye and new flare-ups of inflammation, vitreous surgery is an option. Vitrectomy refers to the removal of the vitreous body, including all inflammatory products and bacteria, and its subsequent replacement with a substitute fluid. This surgical technique is recommended almost exclusively for leptospira-related inflammation. The operation is performed under general anesthesia and is only carried out by a few specialized veterinarians. If there is no damage to the lens or retina, the chances of success are very good, as vision is also improved by removing the cloudy vitreous body contents. Nevertheless, every operation and every anaesthetic always involves risks. Your veterinarian will therefore discuss with you the extent to which surgery is advisable for your horse.

If vitreous surgery is not recommended by the veterinarian due to advanced damage to the eye, it is possible to suppress further inflammation in the long term by implanting a chemotherapeutic agent.

Forecast

The earlier treatment is started and the less damage there is to the eyes, the better the chances of completely preserving the eye's vision. With the help of vitrectomy, many horses affected by ERU can now be protected from further progression of the disease.if the inflammation has already caused irreparable damage to the lens or retina, the prognosis is very poor and blindness is to be expected.

Prophylaxis

Due to the complex causes of ERU, comprehensive prevention is virtually impossible. However, good housing conditions, high-quality feed and bedding, and hygienic drinking troughs are important factors in keeping horses' eyes healthy. As mice are considered to be carriers of leptospira, adequate pest control in the stable is also important.

It is also advisable to have regular preventive examinations carried out by a veterinarian on each individual horse in order to detect any changes or diseases at an early stage.