Osteosarcoma – how does bone cancer manifest itself in my dog?

Osteosarcoma is the most common primary bone tumor in dogs. This aggressive tumor develops in the bone, has a high metastasis rate (spread rate), and occurs mainly in large dogs and giant breeds. Bernese Mountain Dogs, Great Danes, Dobermans, German Shepherds, Golden Retrievers, Rottweilers, and Greyhounds are at increased risk of developing osteosarcoma. In these breeds, the tumors mainly occur in the long bones of the limbs. Smaller dog breeds are significantly less affected. Here, the tumors are more likely to be found on the short, flat bones of the trunk.

INHALT
Causes Symptoms Diagnosis Treatment Forecast
Causes

The exact causes of osteosarcoma are still unknown. Various physical and chemical influences, as well as traumatic and genetic factors, are suspected to be triggering factors.

Symptoms

The disease first manifests itself in the form of lameness and pain in the affected limbs. As the tumor grows rapidly, significant swelling can also be seen. Since osteosarcomas very often metastasize (spread) to the lungs, the onset of breathing difficulties is an indication of existing secondary tumors in the lung tissue. As the pain increases and the metastasis progresses, the dog's general condition also begins to deteriorate. A disturbed carbohydrate and protein metabolism leads to typical tumor cachexia (= emaciation).

Diagnosis

The veterinarian will first conduct a thorough clinical examination, which, in conjunction with a detailed preliminary report from the owner, can provide initial indications of the disease. X-rays of the affected limb are essential for further diagnosis. In most cases, the X-ray already shows a pattern that is very characteristic of a primary bone tumor.

However, in order to determine the exact type of bone tumor, a biopsy (tissue sample) followed by laboratory testing is necessary, which is not always easy to perform. Computed tomography can be used to determine the exact extent of the tumor and whether soft tissue is involved. This examination method is also suitable for detecting any metastases that may be present. A blood count should always be performed, as the activity of certain enzymes provides important information for the prognosis of osteosarcoma.

Osteosarcoma in dogs
The degenerated tumor cells can be detected in tissue samples
Treatment

The treatment of osteosarcoma depends greatly on the extent and stage of the tumor. In most cases, metastasis has already occurred at the time of diagnosis, meaning that conservative measures are unlikely to be successful.

The only way to effectively treat the tumor is to surgically remove the affected bone, which usually involves amputating the affected limb. Some specialized surgeons can perform limb-sparing surgery followed by bone grafting if the tumor is in a certain location. Chemotherapy should always be administered in parallel with surgical treatment in order to limit or delay possible metastasis. Unlike humans, dogs tolerate chemotherapy relatively well.

If surgical treatment is no longer possible or desired, radiation of the diseased bone (radiotherapy) can be used to relieve pain and improve lameness. In combination with chemotherapy, this can extend the dog's survival time by three to five months.

Forecast

Complete cure of osteosarcoma is still not possible. However, with the help of a combination of surgical amputation, pain management, and chemotherapy, the quality of life of the affected dog can be improved and its life expectancy significantly extended. More than half of all dogs treated in this way survive for more than a year, and a third even survive for more than two years. In general, the earlier the tumor is detected and treated, the lower the tendency to metastasize and the better the prognosis.