Leukosis – blood cancer in horses

Leukosis is a tumorous disease of the hematopoietic system and, unlike in dogs or cattle, is relatively rare in horses. Lymphatic leukosis is the most common form in horses and develops as a result of the degeneration of cells in the immune system.

INHALT
Cause and origin Symptoms Diagnosis Treatment Forecast
Cause and origin

As with many cancers, the causes or triggers of cell degeneration are unknown. Starting in the cells of the immune system, the disease first affects the lymphatic organs (lymph nodes, spleen, thymus, bone marrow). If the bone marrow is involved, tumor cells colonize the blood, a condition known as lymphatic leukemia.

Depending on the main location of the tumor, a distinction is made between the multicentric or generalized form of leukemia and extranodal (outside the lymph nodes) leukemia, which in turn can be divided into intestinal (affecting the intestines), mediastinal (affecting the mediastinum), and cutaneous (affecting the skin) forms.

Symptoms

The disease manifests itself through a wide variety of predominantly non-specific symptoms. The first clinical signs may include fatigue, reduced performance, weakness, tiredness, weight loss, and fever. The more advanced the disease, the more noticeable these general symptoms become.

Swollen lymph nodes, swelling of the spleen, pale mucous membranes, and edema in the lower abdomen and limbs also occur. The lymph nodes in the head and neck area are most commonly affected, which is why distemper must always be considered during diagnosis. Huge tumors (primarily in the liver and spleen) can develop in the abdominal cavity, but these are not always accessible to the veterinarian even during a rectal examination and are therefore often discovered at a late stage.

Diagnosis

Due to the diverse, gradually developing, and rather unspecific symptoms of leukosis, diagnosis is not always easy for veterinarians.

Based on their clinical examination and a detailed preliminary report, they can make an initial diagnosis. However, with regard to the clinical symptoms observed, all diseases with similar symptoms, such as distemper or chronic respiratory diseases, must first be ruled out.

A blood test is an important diagnostic tool that can provide the veterinarian with further valuable information about leukemia. However, in living animals, the diagnosis can only be confirmed by histological detection of tumor cells from a tissue sample. However, the altered lymph nodes and tumors are not always accessible for sampling, making a reliable diagnosis difficult. Tumor cells can also be detected by removing and examining fluid from the chest or abdominal cavity.

Treatment

There are few reports of successful treatment of leukosis in horses, as the disease is usually diagnosed at an advanced stage, meaning that appropriate medication can only achieve short-term success and no long-term cure. In rare cases, surgical removal of individual tumors can bring about short-term improvement and prolong the animal's survival. In the skin form, consistent and continuous treatment with immunosuppressive drugs can achieve good results in some cases. However, treatment that is too short or abruptly interrupted can result in relapses with even more aggressive and rapid tumor growth.

Forecast

The prognosis for generalized leukosis is poor. Most horses die within a short period of time after the onset of symptoms or are euthanized due to the diagnosis. The survival rate of animals suffering from the skin form of leukosis is slightly longer than for horses in which internal organs are also affected.