Rabbit hemorrhagic disease (RHD) is currently the most dangerous disease affecting rabbits. It is caused by a virus and causes blood clotting disorders (hemorrhagic = bleeding, causing hemorrhages). It is highly contagious and occurs worldwide in both domestic and wild rabbits. The infectious disease was first described in China in 1984, which is why it is also known as Chinese disease. Young animals and unvaccinated adult animals are particularly at risk.
The pathogen that causes RHD is a virus that is highly resistant and can survive in the environment for up to seven months, depending on the temperature. The disease is caused by two different variants of the virus (RHD1 and RHD2). The pathogen is transmitted by blood-sucking insects (mosquitoes, rabbit fleas), direct contact, and contaminated objects. Surviving animals continue to excrete the virus and thus serve as a reservoir for the pathogen.
The virus enters the body through the mucous membranes and enters the bloodstream, where it spreads to all organs and the bone marrow. The consequences of viral replication are necrotizing (necrosis = tissue death) liver inflammation and severe blood clotting disorders, which lead to pinpoint hemorrhages in all tissues, but primarily in the respiratory tract, gastrointestinal tract, and urinary organs.
The peracute form is characterized by a very rapid progression. Animals that previously appeared healthy can suddenly die without any obvious symptoms. Occasionally, high fever or suffocation spasms can be observed shortly before death. In larger herds, mass mortality can occur.
The first symptoms appear after an incubation period of only 1-3 days. The animals first become restless, then listless and apathetic. Loss of appetite, breathing difficulties and fever are additional symptoms. The bleeding from the mouth and nose characteristic of RHD1 is not observed in infections with RHD2. In almost 100% of all cases, death occurs within 12 to 48 hours.
Subacute forms occur much less frequently. The affected animals only become ill approximately two weeks after infection and show significantly milder symptoms. They suffer from apathy, disturbed food intake, and fever, but have a much better chance of survival.
Due to the often very rapid progression of the disease, which is fatal, diagnosis is limited to pathological examination of deceased rabbits. The blood clotting disorder caused by the virus in the rabbit's body already provides the pathologist with a characteristic picture of changes. To confirm the suspicion of RHD, the virus can be detected directly in the laboratory using blood or tissue samples from the liver or spleen. Many laboratories are now able to differentiate between the two virus types, RHD1 and RHD2. In surviving animals, the virus can be detected in the urine or blood, although it should be noted that it is only excreted in phases and therefore only repeated testing can provide clear evidence.
The disease is incurable and cannot be treated with medication. In milder forms, only the symptoms can be treated, but surviving animals are not immune to the disease, continue to shed viruses, and thus increase the risk of infection.
In affected areas, therefore, disease control measures are all the more important. Strict separation of sick animals from healthy animals is just as important as thorough cleaning and disinfection of contaminated stables and equipment. It is also advisable to place affected farms under quarantine and to ban exhibitions for a certain period of time.
The most effective protection against this dangerous and incurable disease is vaccination against RHD1 and RHD2. The Standing Vaccination Commission for Veterinary Medicine (StiKo Vet), a committee of veterinary experts, therefore recommends vaccination against RHD as a "core component," which means that all breeding and pet rabbits should be protected against this disease at all times. In Germany, various vaccines and combination vaccines against RHD and myxomatosis are available. Depending on the vaccine, vaccination against RHD can be carried out from four to ten weeks of age and provides reliable protection for one year. Your vet can send you a personalized vaccination schedule for your rabbit via petsXL, and you will automatically receive notifications when it is time to make another appointment.
The risk of infection can be further reduced with the help of a number of additional protective and hygiene measures. These include changing the number of animals in your household as little as possible, quarantining new rabbits for at least three weeks, avoiding contact with wild rabbits, and providing effective protection against insects.
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